Current Status of Amino Acid-Based Permeation Enhancers in Transdermal Drug Delivery
نویسندگان
چکیده
منابع مشابه
Transdermal Drug Delivery with Permeation Enhancer
Transdermal drug delivery (TDD) is used to deliver drugs through the skin as an alternative to oral, intravascular, and subcutaneous routes. While there are many advantages to TDD, skin is a very effective barrier and provides resistance to drug delivery. To improve drug delivery through the skin, permeation enhancers are used. We developed an axisymmetric COMSOL Multiphysics model of drug diff...
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Certain agents that enhance drug transport through the skin, including surfactants, bile salts, and fatty acids, have been shown to exert a similar effect on the oral mucosa. Oral drug delivery offers an attractive method of needle-free drug administration. Unfortunately, oral delivery is often hampered by the poor permeability of drugs across the intestinal epithelium. Although several single ...
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The greatest hindrance for transdermal drug delivery (TDD) is the barrier property of skin, especially the stratum corneum (SC). Various methodologies have been investigated and developed to enhance the penetration of drugs through the skin. Among them, the most popular approach is the application of penetration enhancers (PEs), including natural terpenes, a very safe and effective class of PEs...
متن کاملEffect of Chemical Enhancers in Transdermal Permeation of Alfuzosin Hydrochloride
The objective of the present study is to explore the efficient chemical penetration enhancer among the various enhancers available in overcoming the stratum corneum barrier in transdermal delivery of Alfuzosin hydrochloride (AH). The different enhancers were incorporated in 2% Carbopol gel which was selected as a control and evaluated by in vitro diffusion studies through dialysis membrane and ...
متن کاملChemical and Physical Enhancers for Transdermal Drug Delivery
José Juan Escobar-Chávez1,*, Isabel Marlen Rodríguez-Cruz2 and Clara Luisa Domínguez-Delgado2 1Unidad de Investigación Multidisciplinaria, Laboratorio 12: Materiales Nanoestructurados y Sistemas Transdérmicos, Facultad de Estudios Superiores Cuautitlán-Universidad Nacional Autónoma de México, Carretera Cuautitlán–Teoloyucan, San Sebastián Xhala, Cuautitlán Izcalli, Estado de México, 2Departamen...
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ژورنال
عنوان ژورنال: Membranes
سال: 2021
ISSN: 2077-0375
DOI: 10.3390/membranes11050343